OPTIMIZATION DESIGN OF HORIZONTAL WELL FRACTURE STAGE PLACEMENT IN SHALE GAS RESERVOIRS BASED ON AN EFFICIENT VARIABLE-FIDELITY SURROGATE MODEL AND INTELLIGENT ALGORITHM

Hydraulic fracturing technique increases shale gas well productivity significantly.Horizontal well fracture optimization has been studied by many researchers worldwide in the past decade.However, most of these researches relied on computationally expensive numerical simulation models for objectives evaluation during the optimization process.This af

There is increasing evidence that the catch bond mechanism, where binding becomes stronger under tensile force, is a common property among non-covalent interactions between biological molecules that are exposed to mechanical force in vivo.Here, by using the multi-protein tip complex of the mannose-binding type 1 fimbriae of Escherichia coli, we sho

Abstract Phosphodiesterase type 5 inhibitors (PDE5is) constitute the primary therapeutic option for treating erectile dysfunction (ED).Nevertheless, a substantial proportion of patients, approximately 30%, do not respond to PDE5i treatment.Therefore, new treatment methods are needed.In this study, we identified a pathway that contributes to male er

Abstract Objectives Mevalonate kinase deficiency (MKD) is a rare autoinflammatory syndrome.Several reports have described allogeneic hematopoietic stem cell transplantation in severely affected patients, sometimes with promising results.In view of the scarcity of data, this study aims to analyse the efficacy and safety of allogeneic hematopoietic s